Affinity Ligands combined with Phase Separation

Phase separation is a phenomenon evolved by cells to perform highly specific separations in complex environments. We are developing reagents that harness the power of nature — they combine precisely tunable phase separation with affinity ligands designed to have exquisite specificity for their target biologic. Read more on our technology here.

Isolere Bio delivers tailored manufacturing solutions designed to accelerate development to the clinical, reduce cost and challenges of scaling from clinic to commercial, and improve global access to life changing medicines and vaccines.

The binding domain targets a specific biomolecule of interest (i.e. protein, virus, nucleic acid) and the polypeptide confers its phase separation capability to said target. This process occurs in solution, in seconds, circumventing any mass transfer limitations.

Via affinity, the unique material properties of our reagents can be conferred to the biologic target of interest to pull them into large droplets that are a separate phase from otherwise aqueous contaminants.

Our reagents are then paired with high-performing filtration processes that use the size of the droplets to streamline purification. Our reagents have also demonstrated stabilizing and protective effects, yielding higher quality final product at higher step yields.